Immune globulin replacement is a safe and effective therapy for patients with antibody-deficiency syndromes. The need for frequent hospital visits for treatment and high cost remain significant problems. To surmount these problems, we developed a program of patient/family-performed home administration of intravenous immune globulin. Fourteen patients were selected with predetermined eligibility criteria. Nine patients chose to enter the study. Patients and/or relatives were taught the technique of intravenous administration. A signed agreement to perform the infusion under physician instructions was required. All patients successfully performed home treatment, with an average of 19 infusions completed per patient (range 10 to 24). Home treatment decreased absence from work and school. Another benefit noted was a better self-image for patients who require life-long therapy. Regular follow-up visits with the physician are important for adequate care of patients. We conclude that home self-administration of intravenous immune globulin is feasible, safe, and effective in selected patients.