Granular cell tumors of the urethra

Cancer Treat Res Commun. 2023:35:100695. doi: 10.1016/j.ctarc.2023.100695. Epub 2023 Mar 17.


Granular cell tumors (GCTs) are a rare type of mesenchymal tumors that are histologically derived by Schwann cells and rise within soft tissues such as skin and mucosal surfaces. Differentiation between benign and malignant GCTs is often difficult and relies on their biological behavior and metastatic potential. While there are no standard guidelines for management, upfront surgical resection, whenever feasible, is key as a definitive measure. Systemic therapy is often limited by poor chemosensitivity of these tumors; however, accumulating knowledge of their underlying genomic landscape has opened some opportunities for targeted approaches, for example, the vascular endothelial growth factor tyrosine kinase inhibitor pazopanib, which is already in clinical use for the treatment of many types of advanced soft tissue sarcomas.

Keywords: Chemotherapy; Granular cell tumor; Molecular biology; Pazopanib; Surgical excision; Tyrosine kinase inhibitor; Urethra.

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Granular Cell Tumor* / drug therapy
  • Granular Cell Tumor* / pathology
  • Granular Cell Tumor* / surgery
  • Humans
  • Sarcoma* / drug therapy
  • Soft Tissue Neoplasms* / drug therapy
  • Soft Tissue Neoplasms* / pathology
  • Urethral Neoplasms* / drug therapy
  • Urethral Neoplasms* / therapy
  • Vascular Endothelial Growth Factor A


  • Vascular Endothelial Growth Factor A
  • Angiogenesis Inhibitors