[Intoxications with synthetic cannabinoids]

Ned Tijdschr Geneeskd. 2023 Mar 16;167:D7145.
[Article in Dutch]


Synthetic Cannabinoid Receptor Agonists (SCRAs) are a group of New Psychoactive Substances. They are used recreationally to mimic the effects of THC in cannabis. However, THC is a partial agonist of the CB1-receptor and SCRAs are full agonists. Because of this specificity and potency serious adverse events may occur among which psychological, cardiovascular, and gastro-intestinal symptoms. Because of the low incidence in the Netherlands clinical information on SCRA intoxications is limited, making diagnosis and treatment difficult. In this clinical lesson, two cases of SCRA intoxications are described followed by treatment recommendations.

Publication types

  • English Abstract

MeSH terms

  • Cannabinoid Receptor Agonists / adverse effects
  • Cannabinoids* / adverse effects
  • Cannabis*
  • Hallucinogens*
  • Humans
  • Netherlands


  • Cannabinoids
  • Cannabinoid Receptor Agonists
  • Hallucinogens