Antifungal γ-Pyrone and Isoprenylated Cyclohexanoids from the Fungus Beenakia informis

Chem Biodivers. 2023 Apr;20(4):e202300021. doi: 10.1002/cbdv.202300021. Epub 2023 Mar 29.


Chemical investigation of the extract of the macroscopic fungus Beenakia informis led to the isolation of a previously unreported γ-pyrone and two new isoprenylated cyclohexanoids, together with speciocin N. Their structures were elucidated spectroscopically and the absolute configuration was determined by comparison of the experimental vs. calculated ECD curves. Three of the compounds showed very good to moderate activity against phytopathogenic fungi.

Keywords: Atlantic rainforest; Beenakia informis; Gomphaceae; macroscopic fungus; speciocins.

MeSH terms

  • Antifungal Agents* / chemistry
  • Antifungal Agents* / pharmacology
  • Basidiomycota*
  • Fungi
  • Molecular Structure
  • Pyrones / chemistry


  • Antifungal Agents
  • Pyrones