Associations of HPV-16 Gene Methylation With Oral HPV-16 Persistence Among a Multinational Sample of Men

Jessica Y Islam; Deepti Bettampadi; Richard R Reich; Belinda Nedjai; Anna R Giuliano

doi:10.1097/OLQ.0000000000001802

Associations of HPV-16 Gene Methylation With Oral HPV-16 Persistence Among a Multinational Sample of Men

Sex Transm Dis. 2023 Jul 1;50(7):455-457. doi: 10.1097/OLQ.0000000000001802. Epub 2023 Mar 22.

Authors

Jessica Y Islam¹, Deepti Bettampadi¹, Richard R Reich², Belinda Nedjai³, Anna R Giuliano¹

Affiliations

¹ From the Center for Immunization and Infection Research in Cancer, Cancer Epidemiology Program.
² Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
³ Center for Cancer Prevention, Queen Mary University of London, London, United Kingdom.

PMID: 36943783
DOI: 10.1097/OLQ.0000000000001802

Abstract

Using data from the Human Papillomavirus (HPV) Infection in Men cohort study, we demonstrate HPV-16 methylation associations with persistent oral HPV infection, the obligate precursor to oropharyngeal cancer. Human papillomavirus type 16 persistence was significantly associated with methylation of HPV-16 L2 CpG-4268 (Wilcoxon P = 0.04), and methylation of HPV-16 E2 CpG Pos 4 (Wilcoxon P = 0.04).

MeSH terms

Cohort Studies
Human papillomavirus 16 / genetics
Humans
Male
Methylation
Oropharyngeal Neoplasms* / epidemiology
Oropharyngeal Neoplasms* / genetics
Papillomavirus Infections* / complications
Papillomavirus Infections* / epidemiology