Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs

Phys Chem Chem Phys. 2023 Apr 5;25(14):9766-9771. doi: 10.1039/d3cp00342f.

Abstract

Transferrin (Tf) has been effectively used to promote the cellular uptake of HAIYPRH (T7) peptide-conjugated nano-drugs. In this study, the enhancing effect of Tf on T7-decorated nano-drug transport was investigated using force tracing and nano-indentation techniques at a single-particle/cell level. Furthermore, the results were confirmed by ensemble fluorescence imaging.

MeSH terms

  • Biological Transport
  • Cell Line, Tumor
  • Drug Delivery Systems
  • Peptides*
  • Transferrin*

Substances

  • Peptides
  • Transferrin