Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week

J Am Coll Cardiol. 2023 Mar 28;81(12):1192-1200. doi: 10.1016/j.jacc.2023.01.040.


Nonischemic cardiomyopathies are a frequent occurrence. The understanding of the mechanism(s) and triggers of these cardiomyopathies have led to improvement and even recovery of left ventricular function. Although chronic right ventricular pacing-induced cardiomyopathy has been recognized for many years, left bundle branch block and pre-excitation have been recently identified as potential reversible causes of cardiomyopathy. These cardiomyopathies share a similar abnormal ventricular propagation that can be recognized by a wide QRS duration with left bundle branch block pattern; thus, we coined the term abnormal conduction-induced cardiomyopathies. Such abnormal propagation results in an abnormal contractility that can only be recognized by cardiac imaging as ventricular dyssynchrony. Appropriate diagnosis and treatment will not only lead to improved left ventricular ejection fraction and functional class, but may also reduce morbidity and mortality. This review presents an update of the mechanisms, prevalence, incidence, and risk factors, as well as their diagnosis and management, while highlighting current gaps of knowledge.

Keywords: RV pacing; cardiomyopathy; heart failure; left bundle branch block; left ventricular dysfunction; pre-excitation syndrome.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Arrhythmias, Cardiac / complications
  • Bundle-Branch Block* / therapy
  • Cardiac Conduction System Disease
  • Cardiomyopathies* / diagnosis
  • Cardiomyopathies* / epidemiology
  • Cardiomyopathies* / etiology
  • Humans
  • Stroke Volume
  • Treatment Outcome
  • Ventricular Function, Left