Endocrinology of Taste with Aging

Endocrinol Metab Clin North Am. 2023 Jun;52(2):295-315. doi: 10.1016/j.ecl.2022.10.002. Epub 2023 Feb 16.


Taste is one of our five primary senses, and taste impairment has been shown to increase with aging. The ability to taste allows us to enjoy the food we eat and to avoid foods that are potentially spoiled or poisonous. Recent advances in our understanding of the molecular mechanisms of taste receptor cells located within taste buds help us decipher how taste works. The discoveries of "classic" endocrine hormones in taste receptor cells point toward taste buds being actual endocrine organs. A better understanding of how taste works may help in reversing taste impairment associated with aging.

Keywords: Aging; Dysgeusia; Endocrine organ; Taste; Taste buds.

Publication types

  • Review
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aging
  • Endocrinology*
  • Hormones
  • Humans
  • Taste
  • Taste Buds*


  • Hormones