Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA

Emerg Infect Dis. 2023 Apr;29(4):838-841. doi: 10.3201/eid2904.221005.


We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM and plaque reduction neutralization assays. Clinicians should recognize changing epidemiology of tickborne viruses to enhance encephalitis diagnosis and management.

Keywords: Ohio; Powassan virus; United States; emerging infections; encephalitis; tickborne infection; vector-borne infections; viruses; zoonoses.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Child, Preschool
  • Encephalitis Viruses, Tick-Borne*
  • Encephalitis*
  • Encephalitis, Tick-Borne* / epidemiology
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Ohio / epidemiology