Experimental Central Nervous System Phaeohyphomycosis Following Intranasal Inoculation of Xylohypha Bantiana in Cortisone-Treated Mice

Mycopathologia. 1987 Dec;100(3):145-53. doi: 10.1007/BF00437040.


Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brain of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / microbiology
  • Brain / pathology
  • Brain Diseases / microbiology*
  • Brain Diseases / pathology
  • Cortisone / administration & dosage
  • Disease Models, Animal*
  • Female
  • Lung / microbiology
  • Lung / pathology
  • Mice
  • Mice, Inbred DBA*
  • Mice, Inbred ICR*
  • Mitosporic Fungi / physiology
  • Mycoses / microbiology*
  • Mycoses / pathology


  • Cortisone