The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer

Clin Transl Oncol. 2023 Mar 25. doi: 10.1007/s12094-023-03148-y. Online ahead of print.


Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide variety of proteins. This adapter protein works in conjunction with the autophagy process as well as the ubiquitin proteasome degradation pathway. In addition, the ability of SQSTM1 to interact with multiple binding partners link SQSTM1 to various pathways in the context of antioxidant defense system and inflammation. In this review, we outline the processes underlying the control that SQSTM1 has on these pathways and how their dysregulation contributes to the development of OC. At the final, the therapeutic approaches based on SQSTM1 targeting have been discussed.

Keywords: Autophagy; Cell signaling; Ovarian cancer; SQSTM1/p62; Sequestosome 1.

Publication types

  • Review