IgG4 and IgE anti-Strongyloides stercoralis as additional parameters in characterizing patients with diabetes from a hyperendemic area

Diagn Microbiol Infect Dis. 2023 May;106(1):115927. doi: 10.1016/j.diagmicrobio.2023.115927. Epub 2023 Mar 1.

Abstract

We report the detection of IgG, IgG1, IgG4 and IgE anti-Strongyloides stercoralis as complementary tool for screening in patients with diabetes in hyperendemic areas for strongyloidiasis. A panel of 119 serum samples were analyzed: 76 from patients with DM2 and 43 patients with other endocrine diseases and a positive correlation for total IgG levels with IgG4 (rs = 0.559; P = 0.024; n = 16) and IgG and IgE (rs = 0.585; P < 0.0001; n = 76) was found in the diabetes group.

Keywords: Antibody profile; Endemic areas; Immunodiagnosis; Strongyloidiasis.

MeSH terms

  • Animals
  • Antibodies, Helminth
  • Diabetes Mellitus*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunoglobulin E
  • Immunoglobulin G
  • Strongyloides stercoralis*
  • Strongyloidiasis* / diagnosis
  • Strongyloidiasis* / epidemiology

Substances

  • Immunoglobulin G
  • Antibodies, Helminth
  • Immunoglobulin E