Radiation-induced intracranial rhabdomyosarcoma- A rare complication: Report of a case with literature review

Geethanjali Gude; Debajyoti Chatterjee; Chirag Komal Ahuja; Apinderpreet Singh; Renu Madan; Bishan Dass Radotra

doi:10.1016/j.mjafi.2021.08.007

Radiation-induced intracranial rhabdomyosarcoma- A rare complication: Report of a case with literature review

Med J Armed Forces India. 2023 Mar-Apr;79(2):229-234. doi: 10.1016/j.mjafi.2021.08.007. Epub 2021 Nov 28.

Authors

Geethanjali Gude¹, Debajyoti Chatterjee², Chirag Komal Ahuja³, Apinderpreet Singh⁴, Renu Madan⁵, Bishan Dass Radotra⁶

Affiliations

¹ Senior Resident (Histopathology), PGIMER, Chandigarh, India.
² Assistant Professor (Histopathology), PGIMER, Chandigarh, India.
³ Associate Professor (Radiodiagnosis & Imaging), PGIMER, Chandigarh, India.
⁴ Assistant Professor (Neurosurgery), PGIMER, Chandigarh, India.
⁵ Associate Professor (Radiotherapy), PGIMER, Chandigarh, India.
⁶ Professor & Head (Histopathology), PGIMER, Chandigarh, India.

Abstract

Radiation-induced sarcoma (RIS) of the central nervous system is an uncommon late complication of radiation therapy. We report a case of a 47-year-old male patient who underwent surgery followed by irradiation and chemotherapy with temozolomide for a frontal lobe gliosarcoma and presented 43 months later with a recurrent tumor in the same location with interval growth in the size of the lesion. Histology from surgical resection of the recurrent tumor revealed embryonal rhabdomyosarcoma (RMS). Adjacent brain parenchyma showed radiation-induced changes. There was no evidence of gliosarcoma at recurrence. In addition to the rarity of sarcomas arising following irradiation for glial tumors, this case represents one of the first reports of an intracerebral RMS arising in this setting.

Keywords: Gliosarcoma; Radiation-induced sarcoma; Rhabdomyosarcoma.

Publication types

Case Reports