Novel strategies in melanoma treatment using silver nanoparticles

Abstract

Melanoma has remarkably gained extensive attention owing to its high morbidity and mortality. Conventional treatment methods still have some problems and defects. Therefore, more and more novel methods and materials have been continuously developed. Silver nanoparticles (AgNPs) have attracted significant interest in the field of cancer research especially for melanoma treatment because of their excellent properties including antioxidant, antiproliferative, anti-inflammatory, antibacterial, antifungal, and antitumor abilities. In this review, the applications of AgNPs in the prevention, diagnosis, and treatment of cutaneous melanoma are mainly introduced. It also focuses on the therapy strategies of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy for melanoma treatment. Taken together, AgNPs play an increasingly crucial role in cutaneous melanoma treatment, which have promising application in the future.

Keywords: Cutaneous melanoma; Cytotoxicity; Photodynamic therapy; Photothermal therapy.