Tolerance to anti-pentylenetetrazol effects following chronic diazepam

Eur J Pharmacol. 1986 Feb 18;121(2):281-4. doi: 10.1016/0014-2999(86)90501-7.


Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazol seizures in rats for up to 3 weeks. However, the degree of protection seen after 3 weeks of exposure to diazepam was significantly less than after 1 h. These data suggest that continuous exposure to constant low levels of diazepam results in the development of partial tolerance which is not sufficient to eliminate significant anticonvulsant effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Diazepam / administration & dosage
  • Diazepam / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Implants
  • Drug Tolerance
  • Male
  • Pentylenetetrazole / toxicity*
  • Rats
  • Rats, Inbred Strains
  • Seizures / chemically induced
  • Seizures / physiopathology
  • Time Factors


  • Drug Implants
  • Diazepam
  • Pentylenetetrazole