Research progress of gut microbiota and obesity caused by high-fat diet

Shuyi Fan; Suyun Chen; Lin Lin

doi:10.3389/fcimb.2023.1139800

Research progress of gut microbiota and obesity caused by high-fat diet

Front Cell Infect Microbiol. 2023 Mar 13:13:1139800. doi: 10.3389/fcimb.2023.1139800. eCollection 2023.

Authors

Shuyi Fan^{1

2}, Suyun Chen², Lin Lin¹

Affiliations

¹ Scientific Research Department, Brain Hospital of Hunan Province, Second People's Hospital of Hunan Province, Changsha, Hunan, China.
² Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian, China.

Abstract

Obesity, a chronic metabolic disorder caused by an energy imbalance, has been increasingly prevalent and poses a global health concern. The multifactorial etiology of obesity includes genetics factors, high-fat diet, gut microbiota, and other factors. Among these factors, the implication of gut microbiota in the pathogenesis of obesity has been prominently acknowledged. This study endeavors to investigate the potential contribution of gut microbiota to the development of high-fat diet induced obesity, as well as the current state of probiotic intervention therapy research, in order to provide novel insights for the prevention and management of obesity.

Keywords: gut microbiota; high-fat diet; obesity; probiotics; treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diet, High-Fat / adverse effects
Gastrointestinal Microbiome*
Humans
Obesity / etiology
Probiotics* / therapeutic use

Grants and funding

This article is funded by Innovation and entrepreneurship training program for college students of Xiamen Medical 12 College, Fujian Province (202012631050).