Age-related macular degeneration

Lancet. 2023 Apr 29;401(10386):1459-1472. doi: 10.1016/S0140-6736(22)02609-5. Epub 2023 Mar 27.


Age-related macular degeneration is an increasingly important public health issue due to ageing populations and increased longevity. Age-related macular degeneration affects individuals older than 55 years and threatens high-acuity central vision required for important tasks such as reading, driving, and recognising faces. Advances in retinal imaging have identified biomarkers of progression to late age-related macular degeneration. New treatments for neovascular age-related macular degeneration offer potentially longer-lasting effects, and progress is being made towards a treatment for atrophic late age-related macular degeneration. An effective intervention to slow progression in the earlier stages of disease, or to prevent late age-related macular degeneration development remains elusive, and our understanding of underlying mechanistic pathways continues to evolve.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Humans
  • Macular Degeneration* / diagnosis
  • Macular Degeneration* / therapy
  • Middle Aged
  • Visual Acuity