Masking T cell engagers mitigates on-target off-tumor activity

Affiliations

• ¹ Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
• ² Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ³ Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
• ⁴ Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ⁵ Department of Chemical and Biomedical Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ⁶ Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ⁷ Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ⁸ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ⁹ Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jamie.spangler@jhu.edu.
• ¹⁰ Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jamie.spangler@jhu.edu.