Novel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseases

Future Med Chem. 2023 Mar;15(5):395-397. doi: 10.4155/fmc-2023-0035. Epub 2023 Mar 31.

Authors

Changyu Ren¹, Jiao Liu¹, Shiyun Pu¹, Houfeng Zhou¹, Jinqi Li², Jifa Zhang^{1

3}

Affiliations

¹ Department of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, China.
² Department of Pharmacy, Personalized Drug Therapy Key Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China.
³ Joint Research Institution of Altitude Health, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.

PMID: 36999360
DOI: 10.4155/fmc-2023-0035

No abstract available

Keywords: neurodegenerative diseases; novel strategy; proteolysis targeting chimeras; targeted protein degradation.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neurodegenerative Diseases* / drug therapy
Proteolysis
Ubiquitin-Protein Ligases / metabolism

Substances

Ubiquitin-Protein Ligases