Surgical management of dermatofibrosarcoma protuberans

Dylan J Rust; Bradley D Kwinta; Larisa J Geskin; Faramarz H Samie; Fabrizio Remotti; Sam S Yoon

doi:10.1002/jso.27258

Surgical management of dermatofibrosarcoma protuberans

J Surg Oncol. 2023 Jul;128(1):87-96. doi: 10.1002/jso.27258. Epub 2023 Mar 31.

Authors

Dylan J Rust^{1

2}, Bradley D Kwinta^{1

3}, Larisa J Geskin^{1

3}, Faramarz H Samie^{1

3}, Fabrizio Remotti^{1

4}, Sam S Yoon^{1

2}

Affiliations

¹ Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
² Department of Surgery, Division of Surgical Oncology, Columbia University Irving Medical Center, New York, New York, USA.
³ Department of Dermatology, Columbia University Irving Medical Center, New York, New York, USA.
⁴ Division of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.

PMID: 36999599
DOI: 10.1002/jso.27258

Abstract

Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive cutaneous malignancy. Complete resection is the primary treatment but there is debate over the optimal method. Wide local excision was traditionally the standard of care; however, National Comprehensive Cancer Network guidelines now recommend Mohs micrographic surgery as the preferred approach. Medical therapy with imatinib can be used in advanced or unresectable disease. This review will discuss the current management of DFSP, focusing on optimal surgical approach.

Keywords: Mohs micrographic surgery; dermatofibrosarcoma protuberans; sarcoma; surgery; wide local excision.

Publication types

Review

MeSH terms

Dermatofibrosarcoma* / pathology
Dermatofibrosarcoma* / surgery
Humans
Mohs Surgery
Neoplasm Recurrence, Local / pathology
Skin / pathology
Skin Neoplasms* / pathology
Skin Neoplasms* / surgery

Abstract

Publication types

MeSH terms

Grants and funding