CXC chemokines influence immune surveillance in immunological disorders: Polycystic ovary syndrome and endometriosis

Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166704. doi: 10.1016/j.bbadis.2023.166704. Epub 2023 Mar 30.


Reproductive health is a worldwide challenge, but it is of particular significance to women during their reproductive age. Several female reproductive problems, including polycystic ovary syndrome (PCOS) and endometriosis, affect about 10 % of women and have a negative impact on their health, fertility, and quality of life. Small, chemotactic, and secreted cytokines are CXC chemokines. Both PCOS and endometriosis demonstrate dysregulation of CXC chemokines, which are critical to the development and progression of both diseases. Recent research has shown that both in humans and animals, CXC chemokines tend to cause inflammation. It has also been found that CXC chemokines are necessary for promoting angiogenesis and inflammatory responses. CXC chemokine overexpression is frequently associated with poor survival and prognosis. CXC chemokine levels in PCOS and endometriosis patients impact their circumstances significantly. Hence, CXC chemokines have significant potential as diagnostic and prognostic biomarkers and therapeutic targets. The molecular mechanisms through which CXC chemokines promote inflammation and the development of PCOS and endometriosis are currently unknown. This article will discuss the functions of CXC chemokines in the promotion, development, and therapy of PCOS and endometriosis, as well as future research directions. The current state and future prospects of CXC chemokine -based therapeutic strategies in the management of PCOS and endometriosis are also highlighted.

Keywords: CXC chemokines; Endometriosis; Inflammation; Polycystic ovary syndrome (PCOS); Therapeutic strategies.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokines, CXC / therapeutic use
  • Endometriosis*
  • Female
  • Humans
  • Inflammation
  • Polycystic Ovary Syndrome*
  • Quality of Life


  • Chemokines, CXC