Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation

Andrea Mariscal; Jussi Tikkanen; Lindsay Calderone; Olivia Hough; Manyin Chen; Tereza Martinu; Stephen Juvet; Marcelo Cypel; Mingyao Liu; Shaf Keshavjee

doi:10.1016/j.ajt.2023.03.021

Alpha-1-antitrypsin safely promotes rapid recovery of pigs after lung transplantation

Am J Transplant. 2023 Jul;23(7):1082-1084. doi: 10.1016/j.ajt.2023.03.021. Epub 2023 Mar 31.

Authors

Affiliations

¹ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
² Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
³ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
⁴ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
⁵ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
⁶ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
⁷ Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: shaf.keshavjee@uhn.ca.

PMID: 37004914
DOI: 10.1016/j.ajt.2023.03.021

No abstract available

Keywords: alpha-1-antitrypsin; clinical outcome; lung transplantation; neutrophil elastase; preclinical pig model; primary graft dysfunction; systemic toxicity; weaning of oxygen.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Leukocyte Elastase
Lung
Lung Transplantation* / adverse effects
Neutrophils
Swine
alpha 1-Antitrypsin* / therapeutic use

Substances

alpha 1-Antitrypsin
Leukocyte Elastase

Grants and funding

PJT-148847/CIHR/Canada