Role of stem cell derivatives in inflammatory diseases

Yuxi Yang; Yiqiu Peng; Yingying Li; Tingjuan Shi; Yingyi Luan; Chenghong Yin

doi:10.3389/fimmu.2023.1153901

Role of stem cell derivatives in inflammatory diseases

Front Immunol. 2023 Mar 14:14:1153901. doi: 10.3389/fimmu.2023.1153901. eCollection 2023.

Authors

Yuxi Yang¹, Yiqiu Peng¹, Yingying Li², Tingjuan Shi¹, Yingyi Luan², Chenghong Yin²

Affiliations

¹ Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
² Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

Abstract

Mesenchymal stem cells (MSCs) are pluripotent stem cells of mesodermal origin with the ability of self-renewal and multidirectional differentiation, which have all the common characteristics of stem cells and the ability to differentiate into adipocytes, osteoblasts, neuron-like cells and other cells. Stem cell derivatives are extracellular vesicles(EVs) released from mesenchymal stem cells that are involved in the process of body's immune response, antigen presentation, cell differentiation, and anti-inflammatory. EVs are further divided into ectosomes and exosomes are widely used in degenerative diseases, cancer, and inflammatory diseases due to their parental cell characteristics. However, most diseases are closely related to inflammation, and exosomes can mitigate the damage caused by inflammation in terms of suppressing the inflammatory response, anti-apoptosis and promoting tissue repair. Stem cell-derived exosomes have become an emerging modality for cell-free therapy because of their high safety and ease of preservation and transportation through intercellular communication. In this review, we highlight the characteristics and functions of MSCs-derived exosomes and discuss the regulatory mechanisms of MSCs-derived exosomes in inflammatory diseases and their potential applications in clinical diagnosis and therapy.

Keywords: diagnose; exosome; inflammatory diseases; stem cells; treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell-Derived Microparticles*
Exosomes*
Extracellular Vesicles*
Humans
Inflammation
Mesenchymal Stem Cells*

Grants and funding

This study was financially supported by the National Natural Science Foundation of China (Nos. 81873943), and the National Key Research and Development Program of China (Nos. 2016YFC1000100).