Toxin Involvement in Toxic Shock Syndrome

J Infect Dis. 1986 May;153(5):918-26. doi: 10.1093/infdis/153.5.918.

Abstract

Cultures for Staphylococcus and sera from 434 individuals with confirmed or probable toxic shock syndrome (TSS) were studied. Three hundred forty-eight (91.6%) of the staphylococcal isolated produced TSS toxin-1 (TSST-1) alone or in combination with one or more staphylococcal enterotoxins. Isolates producing both staphylococcal enterotoxin C and TSST-1 had a higher association with nonmenstrual and fatal cases than did any other toxin combination. The sera of 284 patients with TSS were tested for antibodies to TSST-1, and 234 (82.4%) had no detectable level of antibody compared with 80 (77.7%) of 103 healthy controls having antibody levels of greater than or equal to 1:800. The sera from patients with TSS also had lower levels of antibody to staphylococcal enterotoxins A, B, and C than did the controls, a result indicating that these subjects may have an immunodeficiency that inhibits the production and/or maintenance of antibodies to the staphylococcal enterotoxins and TSST-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Bacterial / analysis
  • Bacterial Toxins*
  • Enterotoxins / biosynthesis*
  • Enterotoxins / immunology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Shock, Septic / immunology
  • Shock, Septic / microbiology*
  • Staphylococcus / immunology
  • Staphylococcus / isolation & purification
  • Staphylococcus / metabolism*
  • Staphylococcus aureus / immunology
  • Staphylococcus aureus / isolation & purification
  • Staphylococcus aureus / metabolism
  • Staphylococcus epidermidis / immunology
  • Staphylococcus epidermidis / isolation & purification
  • Staphylococcus epidermidis / metabolism
  • Superantigens*

Substances

  • Antibodies, Bacterial
  • Bacterial Toxins
  • Enterotoxins
  • Superantigens
  • enterotoxin F, Staphylococcal
  • enterotoxin D, Staphylococcal
  • enterotoxin A, Staphylococcal
  • enterotoxin B, staphylococcal
  • enterotoxin C, staphylococcal