The contribution of the basal ganglia and cerebellum to motor learning: A neuro-computational approach

PLoS Comput Biol. 2023 Apr 3;19(4):e1011024. doi: 10.1371/journal.pcbi.1011024. eCollection 2023 Apr.

Abstract

Motor learning involves a widespread brain network including the basal ganglia, cerebellum, motor cortex, and brainstem. Despite its importance, little is known about how this network learns motor tasks and which role different parts of this network take. We designed a systems-level computational model of motor learning, including a cortex-basal ganglia motor loop and the cerebellum that both determine the response of central pattern generators in the brainstem. First, we demonstrate its ability to learn arm movements toward different motor goals. Second, we test the model in a motor adaptation task with cognitive control, where the model replicates human data. We conclude that the cortex-basal ganglia loop learns via a novelty-based motor prediction error to determine concrete actions given a desired outcome, and that the cerebellum minimizes the remaining aiming error.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basal Ganglia* / physiology
  • Brain / physiology
  • Cerebellum* / physiology
  • Humans
  • Learning / physiology
  • Movement / physiology

Grants and funding

This study was funded by German Research Foundation (DFG, 416228727) - SFB 1410 Hybrid Societies awarded to F.H. Parts of the salary for Javier Baladron and Torsten Fietzek were covered by the fund above. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.