Aspirin-Exacerbated Respiratory Disease Polymorphisms; a review study

Aida Fathollahpour; Fahimeh Abdi Abyaneh; Behzad Darabi; Mohsen Ebrahimi; Wesam Kooti; Rasoul Nasiri Kalmarzi

doi:10.1016/j.gene.2023.147326

Aspirin-Exacerbated Respiratory Disease Polymorphisms; a review study

Gene. 2023 Jun 20:870:147326. doi: 10.1016/j.gene.2023.147326. Epub 2023 Apr 1.

Authors

Aida Fathollahpour¹, Fahimeh Abdi Abyaneh², Behzad Darabi³, Mohsen Ebrahimi⁴, Wesam Kooti⁵, Rasoul Nasiri Kalmarzi⁶

Affiliations

¹ Iran Universuty of Medical Science, Tehran, Iran.
² Kashan University of Medical Sciences, Kashan, Iran.
³ Allergist and Clinical Immunologist, Department of Pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
⁴ Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
⁵ Lung Diseases & Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
⁶ Lung Diseases & Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: rasool_nsr@yahoo.com.

PMID: 37011853
DOI: 10.1016/j.gene.2023.147326

Abstract

Aspirin exacerbated respiratory disease (AERD) is a condition caused by increased bronchoconstriction in people with asthma after taking aspirin or another NSAID. Molecular analysis of the human genome has opened up new perspectives on human polymorphisms and disease. This study was conducted to identify the genetic factors that influence this disease due to its unknown genetic factors. We evaluated research studies, letters, comments, editorials, eBooks, and reviews. PubMed/MEDLINE, Web of Sciences, Cochrane Library, and Scopus were searched for information. We used the keywords polymorphisms, aspirin-exacerbated respiratory disease, asthma, allergy as search terms. This study included 38 studies. AERD complications were associated with polymorphisms in ALOX15, EP2, ADRB2, SLC6A12, CCR3, CRTH2, CysLTs, DPCR1, DPP10, FPR2, HSP70, IL8, IL1B, IL5RA, IL-13, IL17RA, ILVBL, TBXA2R, TLR3, HLA-DRB and HLA-DQ, HLA-DR7, HLA-DP. AERD was associated with heterogeneity in gene polymorphisms, making it difficult to pinpoint specific gene changes. Therefore, diagnosing and treating AERD may be facilitated by examining common variants involving the disease.

Keywords: Allergy; Aspirin-Exacerbated Respiratory Disease; Asthma; Polymorphisms.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal
Aspirin / adverse effects
Asthma*
Asthma, Aspirin-Induced* / genetics
Humans
Polymorphism, Genetic

Substances

Aspirin
Anti-Inflammatory Agents, Non-Steroidal