Adipose-derived stem cells and obesity: The spear and shield relationship

Genes Dis. 2021 Oct 2;10(1):175-186. doi: 10.1016/j.gendis.2021.09.004. eCollection 2023 Jan.


With the transformation of modern lifestyles and population ageing, obesity has become a global epidemic, as one of the important threat to human health of chronic non-communicable diseases (NCD). Stem cell therapy seems promising as an alternative strategy for managing obesity and related metabolic problems. Adipose tissue-derived stem cells (ADSCs) have received widespread attention, which provides new ideas for the treatment of obesity and various metabolic-related diseases, due to their abundant reserves, easy acquisition, rapid expansion, and multi-directional differentiation potential, low immunogenicity and many other advantages. Accordingly, there seems to be a "shield and spear paradox" in the relationship between ADSCs and obesity. In this review, we emphatically summarized the role of ADSCs in the occurrence and development of obesity and related metabolic disease processes, in order to pave the way for clinical practice.

Keywords: Adipose-derived stem cells; Differentiation; Inflammation; Insulin resistance; Metabolic syndrome; Obesity.

Publication types

  • Review