Time Scales of Human Mpox Transmission in The Netherlands

J Infect Dis. 2024 Mar 14;229(3):800-804. doi: 10.1093/infdis/jiad091.


Mpox has spread rapidly to many countries in nonendemic regions. After reviewing detailed exposure histories of 109 pairs of mpox cases in the Netherlands, we identified 34 pairs where transmission was likely and the infectee reported a single potential infector with a mean serial interval of 10.1 days (95% credible interval, 6.6-14.7 days). Further investigation into pairs from 1 regional public health service revealed that presymptomatic transmission may have occurred in 5 of 18 pairs. These findings emphasize that precaution remains key, regardless of the presence of recognizable symptoms of mpox.

Keywords: Monkeypox virus; mpox; presymptomatic transmission; reproduction number; serial interval.

MeSH terms

  • Humans
  • Mpox (monkeypox)*
  • Netherlands