Celiac disease in insulin-dependent diabetes mellitus

J Pediatr. 1986 May;108(5 Pt 1):690-3. doi: 10.1016/s0022-3476(86)81042-3.


Jejunal biopsy was performed without selection in 110 of 201 children with insulin-dependent diabetes mellitus; serum reticulin antibody, antigliadin antibody by enzyme-linked immunosorbent assay, and serum IgA were studied in all 201 children. Seven children had severe jejunal villous atrophy, giving a prevalence of celiac disease of at least 3.5%. Of the serum tests used, antigliadin antibody with ELISA was the most sensitive. Four patients adhered to a gluten-free diet, and their jejunal structure became normal; three had subsequent gluten provocation, and the jejunal mucosa relapsed in every one. Six had HLA-B8 and -DR3 antigens, and one had B15 and -DR4 phenotypes. In most patients, a gluten-free diet had little effect on insulin dosage, urinary excretion of glucose, or serum level of hemoglobin A1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / immunology
  • Celiac Disease / complications*
  • Celiac Disease / diet therapy
  • Celiac Disease / pathology
  • Child
  • Diabetes Mellitus, Type 1 / complications*
  • Diet Therapy
  • Enzyme-Linked Immunosorbent Assay
  • Gliadin / immunology
  • HLA Antigens / genetics
  • Humans
  • Jejunum / pathology
  • Phenotype
  • Reticulin / immunology


  • Antibodies
  • HLA Antigens
  • Reticulin
  • Gliadin