Delayed-Onset Transient Hyperinsulinism in Infants with Very Low and Extremely Low Birth Weights: A Cohort Study

Henrike Hoermann; Marcia Roeper; Alena Welters; Fabian Baertling; Ertan Mayatepek; Thomas Meissner; Sebastian Kummer

doi:10.1016/j.jpeds.2023.113399

Delayed-Onset Transient Hyperinsulinism in Infants with Very Low and Extremely Low Birth Weights: A Cohort Study

J Pediatr. 2023 Jul:258:113399. doi: 10.1016/j.jpeds.2023.113399. Epub 2023 Apr 3.

Authors

Henrike Hoermann¹, Marcia Roeper², Alena Welters², Fabian Baertling², Ertan Mayatepek², Thomas Meissner², Sebastian Kummer²

Affiliations

¹ Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address: henrike.hoermann@med.uni-duesseldorf.de.
² Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.

PMID: 37019330
DOI: 10.1016/j.jpeds.2023.113399

Abstract

We describe 16 infants born preterm with birth weights <1500 g and transient hyperinsulinism. The onset of hyperinsulinism was delayed and often coincident with clinical stabilization. We hypothesize that postnatal stress caused by prematurity and associated problems may contribute to development of delayed-onset transient hyperinsulinism.

Keywords: blood glucose; hypoglycemia; neonatal glycemia; prematurity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Humans
Hyperinsulinism* / complications
Hypoglycemia* / complications
Hypoglycemia* / diagnosis
Infant
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature
Pancreatic Diseases* / complications