Genetic Markers Predisposing to Nonalcoholic Steatohepatitis

Aalam Sohal; Hunza Chaudhry; Kris V Kowdley

doi:10.1016/j.cld.2023.01.006

Genetic Markers Predisposing to Nonalcoholic Steatohepatitis

Clin Liver Dis. 2023 May;27(2):333-352. doi: 10.1016/j.cld.2023.01.006. Epub 2023 Mar 8.

Authors

Aalam Sohal¹, Hunza Chaudhry², Kris V Kowdley³

Affiliations

¹ Liver Institute Northwest, 3216 Northeast 45th Place Suite 212, Seattle, WA 98105, USA.
² Department of Internal Medicine, UCSF Fresno, 155 North Fresno Street, Fresno, CA 93722, USA.
³ Liver Institute Northwest, 3216 Northeast 45th Place Suite 212, Seattle, WA 98105, USA; Elson S. Floyd College of Medicine, Washington State University, WA, USA. Electronic address: kkowdley@liverinstitutenw.org.

PMID: 37024211
DOI: 10.1016/j.cld.2023.01.006

Abstract

The growing prevalence of nonalcoholic fatty liver disease (NAFLD) has sparked interest in understanding genetics and epigenetics associated with the development and progression of the disease. A better understanding of the genetic factors related to progression will be beneficial in the risk stratification of patients. These genetic markers can also serve as potential therapeutic targets in the future. In this review, we focus on the genetic markers associated with the progression and severity of NAFLD.

Keywords: GCKR; Genetic markers; HSD17B13; MARC1; NASH; PNPLA3; Progression; TM6SF2.

Publication types

Review

MeSH terms

Genetic Markers
Genetic Predisposition to Disease
Humans
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / epidemiology
Non-alcoholic Fatty Liver Disease* / genetics

Substances

Genetic Markers