Research Priorities for Precision Medicine in NAFLD

Clin Liver Dis. 2023 May;27(2):535-551. doi: 10.1016/j.cld.2023.01.016. Epub 2023 Feb 26.


NAFLD is a multisystem condition and the leading cause of chronic liver disease globally. There are no approved NAFLD-specific dugs. To advance in the prevention and treatment of NAFLD, there is a clear need to better understand the pathophysiology and genetic and environmental risk factors, identify subphenotypes, and develop personalized and precision medicine. In this review, we discuss the main NAFLD research priorities, with a particular focus on socioeconomic factors, interindividual variations, limitations of current NAFLD clinical trials, multidisciplinary models of care, and novel approaches in the management of patients with NAFLD.

Keywords: Disease phenotyping; Multidisciplinary care; NAFLD; Non-invasvie tests (NITs); Precision medicine.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Non-alcoholic Fatty Liver Disease* / drug therapy
  • Non-alcoholic Fatty Liver Disease* / therapy
  • Precision Medicine