Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles

Zahra Tashrifi; Mohammad Mohammadi Khanaposhtani; Saeed Bahadorikhalili; Bagher Larijani; Mohammad Mahdavi

doi:10.2174/1570179420666230407103320

Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles

Curr Org Synth. 2024;21(2):166-194. doi: 10.2174/1570179420666230407103320.

Authors

Zahra Tashrifi¹, Mohammad Mohammadi Khanaposhtani², Saeed Bahadorikhalili³, Bagher Larijani¹, Mohammad Mahdavi¹

Affiliations

¹ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Faculty of Fouman, College of Engineering, University of Tehran, Fouman, Iran.
³ Department of Electronic Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain.

PMID: 37026493
DOI: 10.2174/1570179420666230407103320

Abstract

Click Chemistry, as a powerful tool, has been used for the synthesis of a variety of 1,2,3-triazoles. Among click cycloaddition reactions, intramolecular click reactions carried out in azido-alkyne precursors has not been thoroughly reviewed. Hence, in this review, we have summarized and categorised the recent literature (from 2012 on) based on the azidoalkynyl precursor's type and a brief and concise description of the involved mechanisms is presented. Accordingly, we have classified the relevant literature into three categories: (1) substitution precursors (2) addition and (3) multi-component reaction (MCR) products.

Keywords: Intramolecular click reactions; MCR.; azido-alkynes; click chemistry; cycloaddition; substitution precursors; triazole.