A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders

Mohammad Taheri; Arian Askari; Kimia Behzad Moghadam; Bashdar Mahmud Hussen; Soudeh Ghafouri-Fard; Arda Kiani

doi:10.1016/j.prp.2023.154451

A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders

Pathol Res Pract. 2023 May:245:154451. doi: 10.1016/j.prp.2023.154451. Epub 2023 Apr 5.

Authors

Mohammad Taheri¹, Arian Askari², Kimia Behzad Moghadam³, Bashdar Mahmud Hussen⁴, Soudeh Ghafouri-Fard⁵, Arda Kiani⁶

Affiliations

¹ Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ School of Pharmacy, University of California, San Francisco, USA.
⁴ Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
⁵ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: s.ghafourifard@sbmu.ac.ir.
⁶ Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tehran Lung Research and Developmental Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: ardakiani@sbmu.ac.ir.

PMID: 37028107
DOI: 10.1016/j.prp.2023.154451

Abstract

NCK1 Antisense RNA 1 (NCK1-AS1), alternatively named as NCK1-DT, is a long non-coding RNA (lncRNA) with important roles in the carcinogenesis. Multiple studies verified its oncogenic role in different types of cancer, including gastric cancer, non-small cell lung cancer, glioma, prostate cancer and cervical cancer. NCK1-AS1 functions as a sponge for several microRNAs, including miR-137, miR-22-3p, miR-526b-5p, miR-512-5p, miR-138-2-3p and miR-6857. In this review we present an outline of NCK1-AS1 function in malignant conditions as well as atherosclerosis.

Keywords: Cancer; LncRNA; MicroRNAs; NCK1-AS1.

Publication types

Review

MeSH terms

Carcinoma, Non-Small-Cell Lung* / genetics
Cell Line, Tumor
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Glioma* / pathology
Humans
Lung Neoplasms* / genetics
Male
MicroRNAs* / genetics
RNA, Antisense / genetics
RNA, Long Noncoding* / genetics

Substances

RNA, Antisense
MicroRNAs
RNA, Long Noncoding
MIRN137 microRNA, human
MIRN138 microRNA, human