Formulation and characterization of sustainable bioadhesive films for wound treatment based on barley β-glucan extract obtained using the high power ultrasonic technique

Int J Pharm. 2023 May 10:638:122925. doi: 10.1016/j.ijpharm.2023.122925. Epub 2023 Apr 6.


β-glucan is a well-known functional and bioactive food ingredient. Recently, some studies highlighted several interesting pharmacological activities, such as hypocholesterolemic, hypoglycemic, immunomodulatory, antitumor, antioxidant and anti-inflammatory. The aim of this study is to evaluate a novel application of β-glucan, obtained from barley, for the development of formulations for skin use. Several water suspensions were obtained from barley flour of different particle sizes treated by high power ultrasonic (HPU) technique. Barley flour fraction in the range of 400-500 μm allowed to obtain a stable suspension, represented both by a water soluble and water insoluble fraction of β-glucans, that showed excellent film forming ability. The plasticizer sorbitol as well as the bioadhesive biopolymer acacia gum were added to this suspension in order to obtain a gel suitable to prepare films by casting. The obtained films demonstrated suitable mechanical properties and ability to stimulate in vitro keratinocytes growth suggesting its possible application in dermatological field as for wound treatment. This study demonstrated the dual use of barley suspension: as excipient and as active ingredient.

Keywords: Barley; Film; High power ultrasonic (HPU); Mechanical properties; Solvent casting; β-Glucan enriched suspension.

MeSH terms

  • Flour
  • Hordeum*
  • Plant Extracts
  • Ultrasonics
  • Water
  • beta-Glucans*


  • beta-Glucans
  • Water
  • Plant Extracts