Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

Esther Strating; Anne van de Loo; Sjoerd Elias; Marnix Lam; Onno Kranenburg

doi:10.1016/j.cpet.2023.02.003

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

PET Clin. 2023 Jul;18(3):325-335. doi: 10.1016/j.cpet.2023.02.003. Epub 2023 Apr 6.

Authors

Esther Strating¹, Anne van de Loo¹, Sjoerd Elias², Marnix Lam³, Onno Kranenburg⁴

Affiliations

¹ Division of Imaging and Cancer, Laboratory Translational Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, G.04.2.28, Utrecht, the Netherlands.
² Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, STR.6.131, Utrecht, the Netherlands.
³ Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, E.01.1.32, Utrecht, the Netherlands. Electronic address: m.lam@umcutrecht.nl.
⁴ Division of Imaging and Cancer, Laboratory Translational Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, G.04.2.28, Utrecht, the Netherlands. Electronic address: o.kranenburg@umcutrecht.nl.

PMID: 37030984
DOI: 10.1016/j.cpet.2023.02.003

Abstract

Fibroblast activation protein inhibitor (FAPI)-PET imaging holds great promise for improving the clinical management of colorectal cancer. High fibroblast activation protein expression is particularly observed in lymph node metastases, in the aggressive Consensus Molecular Subtype 4, in peritoneal metastases, and in tumors that respond poorly to immunotherapy. We have defined six clinical dilemmas in the diagnosis and treatment of colorectal cancer, which FAPI-PET may help solve. Future clinical trials should include patients undergoing tumor resection, allowing correlation of FAPI-PET signals with in-depth histopathological, cellular, and molecular tissue analyses.

Keywords: Colorectal cancer; Fibroblast activation protein; Fibroblast activation protein inhibitor; PET; Peritoneal metastases.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / diagnostic imaging
Fibroblasts
Fluorodeoxyglucose F18
Gallium Radioisotopes
Humans
Immunotherapy*
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography

Substances

Gallium Radioisotopes
Fluorodeoxyglucose F18