Mechanisms of Cardiac Repair in Cell Therapy

Heart Lung Circ. 2023 Apr 6;S1443-9506(23)00122-1. doi: 10.1016/j.hlc.2023.01.019. Online ahead of print.


Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring damaged hearts to working condition. But progress has not been straightforward as many of our initial assumptions turned out to be wrong. In this review, we critically examine the last 20 years of progress in cardiac cell therapy and focus on several of the popular beliefs surrounding cell therapy to illustrate the mechanisms involved in restoring heart function after cardiac injury. Are they true or false?

Keywords: Cell therapy; Heart failure; Myocardial infarction; Regeneration.