Review of lymphoma in the duodenum: An update of diagnosis and management

World J Gastroenterol. 2023 Mar 28;29(12):1852-1862. doi: 10.3748/wjg.v29.i12.1852.


The presentation, subtype, and macroscopic images of lymphoma vary depending on the site of the tumor within the gastrointestinal tract. We searched PubMed for publications between January 1, 2012 and October 10, 2022, and retrieved 130 articles relating to duodenal lymphoma. A further 22 articles were added based on the manual screening of relevant articles, yielding 152 articles for full-text review. The most predominant primary duodenal lymphoma was follicular lymphoma. In this review, we provide an update of the diagnosis and man-agement of representative lymphoma subtypes occurring in the duodenum: Follicular lymphoma, diffuse large B-cell lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, mantle cell lymphoma, and T-cell lymphomas.

Keywords: Diagnosis; Diffuse large B-cell lymphoma; Duodenal neoplasms; Esoph-agogastroduodenoscopy; Follicular lymphoma; Gastrointestinal lymphoma.

Publication types

  • Review

MeSH terms

  • Adult
  • Duodenum / diagnostic imaging
  • Duodenum / pathology
  • Gastrointestinal Tract / pathology
  • Humans
  • Lymphoma, B-Cell, Marginal Zone* / diagnosis
  • Lymphoma, B-Cell, Marginal Zone* / pathology
  • Lymphoma, B-Cell, Marginal Zone* / therapy
  • Lymphoma, Follicular* / diagnosis
  • Lymphoma, Follicular* / pathology
  • Lymphoma, Follicular* / therapy
  • Lymphoma, Large B-Cell, Diffuse* / diagnostic imaging
  • Lymphoma, Large B-Cell, Diffuse* / therapy
  • Male