Application of nanomaterials in the treatment of intracerebral hemorrhage

Xiangyu Zhang; Suliman Khan; Ruixue Wei; Yan Zhang; Yang Liu; Voon Wee Yong; Mengzhou Xue

doi:10.1177/20417314231157004

Application of nanomaterials in the treatment of intracerebral hemorrhage

J Tissue Eng. 2023 Apr 3:14:20417314231157004. doi: 10.1177/20417314231157004. eCollection 2023 Jan-Dec.

Authors

Xiangyu Zhang^{1

2}, Suliman Khan^{1

2}, Ruixue Wei^{1

2}, Yan Zhang^{1

2}, Yang Liu^{1

2}, Voon Wee Yong³, Mengzhou Xue^{1

2}

Affiliations

¹ Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
² Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan, China.
³ Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

Abstract

Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by the rupture of blood vessels in the brain parenchyma, with an acute mortality rate of 30%‒40%. Currently, available treatment options that include surgery are not promising, and new approaches are urgently needed. Nanotechnology offers new prospects in ICH because of its unique benefits. In this review, we summarize the applications of various nanomaterials in ICH. Nanomaterials not only enhance the therapeutic effects of drugs as delivery carriers but also contribute to several facets after ICH such as repressing detrimental neuroinflammation, resisting oxidative stress, reducing cell death, and improving functional deficits.

Keywords: Intracerebral hemorrhage; hydrogel; nanomaterials; nanomicelle.

Publication types

Review