Extracranial Microvascular Complications of Moyamoya Disease Leading to Left Ventricular Systolic Dysfunction

Sohiub N Assaf; Abdallah N Assaf; Muaz N Assaf; John Taylor; Justin M Adam; Justin Harrell; Jeffery Johnson

doi:10.14740/jmc4057

Extracranial Microvascular Complications of Moyamoya Disease Leading to Left Ventricular Systolic Dysfunction

J Med Cases. 2023 Mar;14(3):88-94. doi: 10.14740/jmc4057. Epub 2023 Mar 31.

Authors

Sohiub N Assaf¹, Abdallah N Assaf¹, Muaz N Assaf¹, John Taylor², Justin M Adam¹, Justin Harrell², Jeffery Johnson²

Affiliations

¹ Department of Medicine, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.
² Department of Cardiovascular Disease, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.

Abstract

Moyamoya disease (MMD) was first used as a descriptor for a steno-occlusive process that affects primarily the internal carotid arteries (ICA) in a bilateral fashion in 1969. Characterized by recurrent ischemic events in the developing brains of young patients, the process is one that often decimates the quality of life of affected individuals. The vascular changes in MMD have been demonstrated to occur in an extracranial manner, thus it is logical to assume that the same steno-occlusive mechanism could induce dysfunction and ischemia in other organ systems. Our case presents a patient with MMD with cardiac manifestations that we suspect may be related to extracranial manifestations of MMD.

Keywords: Congestive heart failure; Heart failure with reduced ejection fraction; Moyamoya disease; Non-ST elevated myocardial infarction; Systemic inflammatory response syndrome.

Publication types

Case Reports