Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

Jiahui Yang; Zhengjun Bao; Guoyu Hu; Xiaopeng Luo; Zhen Zhao

doi:10.5114/aoms/159180

Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

Arch Med Sci. 2023 Feb 16;19(2):518-522. doi: 10.5114/aoms/159180. eCollection 2023.

Authors

Jiahui Yang¹, Zhengjun Bao¹, Guoyu Hu², Xiaopeng Luo¹, Zhen Zhao¹

Affiliations

¹ Department of Neurology, Zhuzhou Hospital Afliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China.
² Department of Hematology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China.

Abstract

Introduction: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS).

Methods: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS.

Results: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS.

Conclusions: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further.

Keywords: DNA methylation; ischemic stroke; platelet aggregation; platelet endothelial aggregation receptor 1.