Photodynamic Therapy, a successful treatment for granular parakeratosis

Photodiagnosis Photodyn Ther. 2023 Jun:42:103562. doi: 10.1016/j.pdpdt.2023.103562. Epub 2023 Apr 8.


Granular parakeratosis is characterized by variably hyperkeratotic brownish papules or plaques, mostly found on flexures. Different treatments have been suggested with variable results. We present a series of 3 cases successfully treated with one session of methyl-aminolevulinate photodynamic therapy, showing resolution of the lesions and symptoms within less than 2 weeks, as a potentially new, safe and effective therapeutic option.

Keywords: Granular parakeratosis; Methyl-aminolevulinate, MAL; Photodynamic therapy.

Publication types

  • Case Reports

MeSH terms

  • Aminolevulinic Acid / therapeutic use
  • Humans
  • Parakeratosis* / drug therapy
  • Parakeratosis* / pathology
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use


  • Photosensitizing Agents
  • Aminolevulinic Acid