Parkinson's disease detection and classification using EEG based on deep CNN-LSTM model

Biotechnol Genet Eng Rev. 2023 Apr 11:1-20. doi: 10.1080/02648725.2023.2200333. Online ahead of print.

Abstract

The progressive loss of motor function in the brain is a hallmark of Parkinson's disease (PD). Electroencephalogram (EEG) signals are commonly used for early diagnosis since they are associated with a brain disorder. This work aims to find a better way to represent electroencephalography (EEG) signals and enhance the classification accuracy of individuals with Parkinson's disease using EEG signals. In this paper, we present two hybrid deep neural networks (DNN) that combine convolutional neural networks with long short-term memory to diagnose Parkinson's disease using EEG signals, that is, through the establishment of parallel and series combined models. The deep CNN network is utilized to acquire the structural features of ECG signals and extract meaningful information from them, after which the signals are sent via a long short-term memory network to extract the features' context dependency. The proposed architecture was able to achieve 97.6% specificity, 97.1% sensitivity, and 98.6% accuracy for a parallel model and 99.1% specificity, 98.5% sensitivity, and 99.7% accuracy for a series model, both in 3-class classification (PD patients with medication, PD patients without medication and healthy).

Keywords: Parkinson’s disease; deep neural network; electroencephalogram (EEG) signals; long short-term memory network.