Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rheumatoid arthritis

Q J Med. 1986 Jan;58(225):53-8.


Evidence is presented for a non-specific ulcerative process in the small bowel of patients with rheumatoid arthritis. All three cases presented with lower gastrointestinal bleeding; on withdrawal of non-steroidal anti-inflammatory drugs no further bleeding occurred. Non-steroidal anti-inflammatory drugs may lead to small bowel ulceration in inhibiting mucosal glycoprotein synthesis and increasing intestinal permeability.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Female
  • Humans
  • Ileal Diseases / chemically induced*
  • Ileal Diseases / pathology
  • Intestinal Mucosa / pathology
  • Male
  • Middle Aged
  • Ulcer / chemically induced
  • Ulcer / pathology


  • Anti-Inflammatory Agents