Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?

Mol Ther Nucleic Acids. 2023 Jun 13:32:263-266. doi: 10.1016/j.omtn.2023.03.013. Epub 2023 Apr 6.

¹ Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Republic of Korea.
² Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore 756020, Odisha, India.
³ Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India.
⁴ Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal 700126, India.

No abstract available

Keywords: Mpro; Omicron subvariant; SARS-CoV-2; nirmatrelvir; significant mutation.

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