The impact of testosterone in men's health

Endocr J. 2023 Jul 28;70(7):655-662. doi: 10.1507/endocrj.EJ22-0604. Epub 2023 May 12.


Testosterone plays a key role in the maintenance of physical and mental functions in men. Age-related testosterone decline is closely associated with sarcopenia and muscle deterioration, while testosterone decline is linked with the etiology and prevention of diseases such as angina pectoris, arteriosclerosis, obesity, metabolic syndrome, and dementia. Late-onset hypogonadism (LOH) is defined as a disease characterized by age-related testosterone decline and associated clinical symptoms. Testosterone replacement therapy improves health-related QOL in patients with LOH.

Keywords: Aging; Late-onset hypogonadism; Testosterone.

MeSH terms

  • Aging
  • Hormone Replacement Therapy / adverse effects
  • Humans
  • Hypogonadism* / drug therapy
  • Hypogonadism* / etiology
  • Male
  • Men's Health
  • Obesity / complications
  • Quality of Life
  • Testosterone* / metabolism
  • Testosterone* / therapeutic use


  • Testosterone