DNA Damage-Mediated Neurotoxicity in Parkinson's Disease

Int J Mol Sci. 2023 Mar 28;24(7):6313. doi: 10.3390/ijms24076313.


Parkinson's disease (PD) is the second most common neurodegenerative disease around the world; however, its pathogenesis remains unclear so far. Recent advances have shown that DNA damage and repair deficiency play an important role in the pathophysiology of PD. There is growing evidence suggesting that DNA damage is involved in the propagation of cellular damage in PD, leading to neuropathology under different conditions. Here, we reviewed the current work on DNA damage repair in PD. First, we outlined the evidence and causes of DNA damage in PD. Second, we described the potential pathways by which DNA damage mediates neurotoxicity in PD and discussed the precise mechanisms that drive these processes by DNA damage. In addition, we looked ahead to the potential interventions targeting DNA damage and repair. Finally, based on the current status of research, key problems that need to be addressed in future research were proposed.

Keywords: DNA damage; DNA repair; Parkinson’s disease; neurodegeneration.

Publication types

  • Review

MeSH terms

  • DNA Damage
  • DNA Repair
  • Humans
  • Neurodegenerative Diseases* / genetics
  • Parkinson Disease* / metabolism