Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits.
Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.
Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.
Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.
Keywords: Cetuximab; Intraepithelial neoplasia; Ocular surface squamous neoplasia.
© 2023. The Author(s).