[Effect of fenibut on the nocturnal sleep of patients with the alcoholic abstinence syndrome]

Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(2):251-4.
[Article in Russian]


The authors studied the effect of the tranquilizer phenibut on sleep disturbances in alcoholics at the initial period following alcohol withdrawal. Sleep was registered polygraphically during 2 nights in 12 patients taking the drug and in 10 control patients. The drug did not affect the latent period of falling asleep, increasing, however, the duration of two major phases of sleep and reducing the duration of the drowsiness stage. There was no marked influence on the subjective assessment of sleep.

MeSH terms

  • Adult
  • Electrodiagnosis
  • Ethanol / adverse effects*
  • Humans
  • Middle Aged
  • Sleep Stages / physiology
  • Sleep Wake Disorders / chemically induced
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / drug therapy*
  • Substance Withdrawal Syndrome / drug therapy*
  • Tranquilizing Agents / therapeutic use*
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / therapeutic use


  • Tranquilizing Agents
  • Ethanol
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid