No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment

Ann Hanna; Justin M Balko

doi:10.1016/j.ccell.2023.03.013

No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment

Cancer Cell. 2023 May 8;41(5):831-833. doi: 10.1016/j.ccell.2023.03.013. Epub 2023 Apr 13.

Authors

Ann Hanna¹, Justin M Balko²

Affiliations

¹ Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
² Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA. Electronic address: justin.balko@vumc.org.

PMID: 37059102
DOI: 10.1016/j.ccell.2023.03.013

Abstract

Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or chemotherapy-treated cells) express antigen presentation machinery, present antigens, and interact with T cells and dendritic cells to robustly activate the immune system and promote anti-tumor immunity.

MeSH terms

Aged
Antigen Presentation
Cellular Senescence*
Humans
Neoplasms*
Tumor Microenvironment